Upon reaching her, Dr. John Dolittle finds that the Queen has eaten a poisonous type of nightshade. To be cured, she must eat a fruit from a land far away. Dolittle, Tommy Stubbins, and a crew of animals put to sail, hoping to find the cure while trying to avoid Dolittle's long ago rival. Dolittle leaves his dog Jip and a walking stick insect behind to guard the Queen while he's traveling.
Dolittle's entourage returns just in time to heal the queen. Dolittle’s walking stick insect reveals that Lord Thomas Badgley (Jim Broadbent), one of the Queen's chairmen, poisoned her in order to take the crown for himself; the queen has him arrested for treason.
Dolittle re-opens the doors to his sanctuary, now including Stubbins as his official apprentice.
Trivia
This is the second time Tom Holland and Robert Downey Jr. worked together, the first non-marvel movie, and officially the first time worked together.
Dolittle and Onward, both of which Tom Holland starred in, came out in 2020.